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ADHD Medication For Adults - What is the Most Effective ADHD Medication For Adults? Stimulant medications are the cornerstone of ADHD treatment, but they don't work for all people. Antidepressants as well as nonstimulant drugs can help. Medications for adults with ADHD could be pills, patches, or liquids. They can improve concentration and decrease the risk of impulsive behavior. They are prescribed by physicians if stimulants do not work or cause side-effects. 1. Stratt