https://gsk-3inhibitors.com/be....ttering-preclinical-
In today's research, to examine the intracellular quantity of meiotic cohesins, we generated two strains of knock-in (KI) mice that expressed a 3×FLAG-tag in the C-terminus of RAD21L or REC8 protein using the CRISPR/Cas9 genome modifying system. Both KI mice were fertile. Western blot analyses and immunocytochemical scientific studies unveiled that expression levels and localization patterns of both RAD21L-3×FLAG and REC8-3×FLAG in KI mice had been just like those who work in wild-type mice. After confirming th
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