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02-2.12). No significant differences were found after subgroup analyses based on other molecules involved and study duration. In comparison with non-b/tsDMARDs, our results suggest that antitumor necrosis factor therapy is associated with observed increased risks of mortality and further investigation is needed. In comparison with non-b/tsDMARDs, our results suggest that antitumor necrosis factor therapy is associated with observed increased risks of mortality and further investigation is needed. Patients with rectal gastrointestinal str