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How Does ADHD Medication Work? Medicines can reduce ADHD symptoms by increasing the levels of chemicals dopamine and noradrenaline that transmit messages between brain cells. The most commonly prescribed stimulants are methylphenidate as well as atomoxetine. Finding the right dosage and dosage can be a trial and error process. with you should be honest and open. Stimulants The stimulant drugs prescribed to treat ADHD increase levels of the hormones dopamine and noradrenaline. The exact mechanism behind this isn't clear, but the result is tha