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Previous studies have shown an association between prenatal exposure to particulate matter (PM) and adverse brain development. However, it is unclear whether gestational exposure to community-sampled residential PM has an impact on the developing brain. We aimed to test whether in utero exposure to PM from residential roof spaces (ceiling voids) alters critical foetal neurodevelopmental processes. Pregnant C57BL/6 mice were intranasally exposed to 100μg of roof space particles (~5mgkg ) in 50μl of saline, or saline alone under light m