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the design of future studies and in the interpretation of the results on survival of children with CAs.This case series study evaluates aortic outcomes in athletes performing endurance exercise or competition after ascending thoracic aortic aneurysm resection with bicuspid aortic valve aortopathy. Controversy exists regarding the effects of a high versus a low intraoperative fraction of inspired oxygen (FiO ) in adults undergoing general anesthesia. This systematic review and meta-analysis investigated the effect of a high versus a low