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Intrahepatic Cholangiocarcinoma (ICC) is a malignant cancer of the bile ducts within the liver, with a devastating overall 5-year survival of less than 5%. Besides surgery, chemotherapy with gemcitabine and cisplatin is the only approved therapy, with limited effectiveness. Gaining insight into the natural development and evolution of ICC would help provide context for various clinical efforts including early detection and improved histological classification. Unfortunately, the precise etiology of the earliest stages of ICC largely rem