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How Does ADHD Medication Work? The drugs help reduce ADHD symptoms by increasing the levels of Dopamine and Noradrenaline. Both are chemicals that transmit messages between brain cells. The most frequently prescribed stimulants are methylphenidate and atomoxetine. Finding the right dose and medication can be a trial-and error process. Communication that is honest and open with your doctor is crucial. Stimulants The stimulant drugs prescribed to treat ADHD boost levels of the hormones dopamine as well