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How Does Medication For ADHD Work? The majority of people notice that their symptoms improve when they take medication. Finding the right medication in the right dosage takes time, open communication and patience with your GP. Treatments for ADHD work by adjusting the levels of certain chemical messengers within your brain. Stimulant drugs, such as methylphenidate help reduce hyperactivity and impulsivity and help improve concentration. Atomoxetine (Strattera) and guanfacine (Tenex, Intuniv) are non-stim