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The 1,3,4-oxadiazole types demonstrated the superior effectiveness compared to imiquimod and EAPB0203. Our results highlight the excellent potential of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole types as anticancer agents.The globally prevalence of epilepsy with high percentage of multidrug-resistant clients make it urgent discover new methods to treating, including the utilization of combinations of classic anticonvulsants with drugs that have an exclusively original mech