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PURPOSE To assess the effectiveness of intracameral phenylephrine/ketorolac during cataract surgery compared with postoperative topical steroids in reducing incidence of postoperative clinical cystoid macular edema (CME) confirmed via optical coherence tomography (OCT), breakthrough iritis, pain, and photophobia. SETTING Ambulatory surgical center/clinical practice. DESIGN Retrospective 2-cohort study. METHODS This study of cataract surgery patients compared the incidence of postoperative CME, breakthrough iritis, pain, and photophobia be