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CONCLUSION Our results revealed a new mechanism of infiltrating macrophages contributing to neurofibroma progression, and targeting this newly identified signaling may help to treat neurofibroma. BACKGROUND Exercise can be beneficial for patients with colorectal cancer; however, few studies have evaluated the effect of exercise on cancer-related fatigue and quality of life. AIM OF THE STUDY To assess the efficacy of physical exercise for patients with colorectal cancer during treatment, we conducted a meta-analysis of randomized contro