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Halogenated natural products (HNPs) show a wide range of interesting biological activities. A chemistry-guided screening using a software tool dedicated to identifying halogenated compounds in HPLC-MS data indicated the presence of several yet uncharacterised HNPs in an extract of the cyanobacterium Fischerella ambigua (Näg.) Gomont 108b. Three new natural products, tjipanazoles K, L, and M, were isolated from this strain together with the known tjipanazoles D and I. Taking into account the structures of all tjipanazole derivatives det