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The Most Effective ADHD Medication For Adults The majority of the drugs used to treat ADHD fall into two categories: stimulants and nonstimulants. The stimulants such as methylphenidate (Provigil) and amphetamines function by increasing activity in parts of the brain that control the behavior and attention. Non-stimulants, such as guanfacine Clonidine, atomoxetine, and others, are slower than stimulants, but they help improve concentration
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