https://www.selleckchem.com/pr....oducts/alw-ii-41-27.
tion telemetric cardiovascular safety data driven by different drugs (ivabradine, sildenafil, dofetilide, and pimobondan), wherein system- (turnover rates) and drug-specific parameters (e.g., potencies and efficacies) were sought. The model-predicted equilibrium concentration-biomarker response relationships and was used for safety assessment (predictions of 20% effective concentration, for example) of heart rate, blood pressure, and QT-interval.Leucine-rich α-2 glycoprotein (LRG), one of the acute phase proteins mainly produced by
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