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DNA fragmentation, S and G2/M arrest, disruption of mitochondrial metabolism, and alterations in cell morphology culminated in proliferation blockage and apoptosis. 5-FU/MEL combination design optimizes the cytotoxic effects of each drug at lower concentrations, which may represent an innovative strategy for SCC therapy.Volvox barberi is a multicellular green alga forming spherical colonies of 10,000-50,000 differentiated somatic and germ cells. We observed that in culture, these colonies actively self-organized in just a few minutes int
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