https://www.selleckchem.com/pr....oducts/pf-07321332.h
Immunohistochemical analyses using these 50 cases indicated that only 8% (4/5 of cancerous tissues expressed PYCARD, whereas 80% (40/5 of corresponding normal prostate epithelial and/or basal cells expressed PYCARD. In addition, there was no relationship between PYCARD immunostaining and the Gleason score in cancerous tissue and surrounding normal tissue. Inducible expression of PYCARD inhibited cell proliferation by induction of apoptosis. These results suggest that aberrant methylation of PYCARD is a distinctive feature of pro
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