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During the use of rtCGM a high quality of life was reported, and the quality of sleep in their caregivers was increased.Novel antimicrobials interfering with pathogen-specific targets can minimize the risk of perturbations of the gut microbiota (dysbiosis) during therapy. We employed an in silico approach to identify essential proteins in Escherichia coli that are either absent or have low sequence identity in seven beneficial taxa of the gut microbiota Faecalibacterium, Prevotella, Ruminococcus,Bacteroides, Lactobacillus, Lachnospirace