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CONCLUSIONS PRKDC is not only a predictive biomarker but in addition a drug target for protected checkpoint inhibitors. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See legal rights and permissions. Posted by BMJ.The rapid increase to fame of immuno-oncology (IO) medications has actually generated unprecedented fascination with the industry, customers and doctors, and it has had a major infl