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We pooled database-specific estimates through random effects meta-analysis. Results Our study overall included 2.6 and 0.46 million users of alpha-1 blockers and of alternative BPH medications. We observed no significant difference in their risks for any of the COVID-19 outcomes, with our meta-analytic HR estimates being 1.02 (95% CI 0.92-1.13) for diagnosis, 1.00 (95% CI 0.89-1.13) for hospitalization, and 1.15 (95% CI 0.71-1.88) for hospitalization requiring intensive services. Conclusion We found no evidence of the hypothesized reduct