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Our analysis of fecal samples from women with HSDD and healthy controls identified significantly different gut microbes and metabolic signatures. These preliminary findings could be useful for developing strategies to adjust the level of human sexual desire by modifying gut microbiota. Chinese Clinical Trial Registry ChiCTR1800020321; http//www.chictr.org.cn/showproj.aspx?proj=34267. Chinese Clinical Trial Registry ChiCTR1800020321; http//www.chictr.org.cn/showproj.aspx?proj=34267.Multisite medical data sharing is critical in modern clini