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PCNL has revolutionized the treatment of renal calculi putting almost an end to the era of open stone surgery. The procedure can safely be carried out under general anesthesia (GA) or regional anesthesia viz. spinal anesthesia (SA), epidural anesthesia (EA) or combined spinal and epidural anesthesia (CSE). We evaluated the surgical outcome after PCNL in two groups of patients randomly divided to undergo procedure under GA or EA. Two hundred and thirty patients with American Society of Anesthesiologists (ASA) score 3 were randomly d