Imatinib is taken orally. The bioavailability of Gleevec when taken orally is more than 97% and is independent of age and food intake. Pharmacological studies have not found an effect of body weight on the concentration of Imatinib in plasma, so the drug is dosed regardless of this indicator. Imatinib is characterized by rapid absorption with maximum plasma concentrations 1-2 hours after administration. The half-life of the drug ranges from 18 to 22 hours, which allows it to be taken once a day. Approximately 96% of the drug is bound to plasma proteins, especially albumin and glycoproteins and, to a very small extent, lipoproteins.
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