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Incidence density rates of CRE during the intervention period were compared to the baseline period using interrupted time series regression. Rates were adjusted for ward/admission prevalence and analysed according to C-UV protocol. The in-use C-UV protocol demonstrated a significant negative association with the incidence density rate of CRE when adjusting for CRE admission rate (P=0.0069). CRE incidence density rates decreased significantly during the intervention period (P=0.042). Non-intervention units demonstrated no change in incide