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The 5-year recurrence-free survival (RFS) calculated for KNN predicted responders and non-responders using QUS-Tex -Tex model were comparable to RFS for the actual response groups. We report the first study demonstrating QUS texture-derivative methods in predicting NAC responses in LABC, which leads to better results compared to using texture features alone. We report the first study demonstrating QUS texture-derivative methods in predicting NAC responses in LABC, which leads to better results compared to using texture features alone.Ci