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no-disturbance complications, subtle pretreatment methods should be seriously considered.Background One of the main side effects of head and neck (HN) radiation therapy (RT) is alteration in taste sensation. It causes significant morbidity and has a major effect on quality of life (QoL). The aim of this study was to prospectively define the effect of RT on taste sensation (general, and four basic tastes) and correlate these findings with changes in saliva secretion and QoL questionnaires. Methods Patients with HN cancer treated