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acologic therapy together with dietary, physical exercise and lifestyle interventions. Lung cancer is a leading cause of cancer-related death, with lung adenocarcinoma (LUAD) representing the most common subtype. Recently, exosome-based biomarkers have provided new diagnostic approaches for malignancies. We aimed to identify specific exosomal microRNAs (miRNAs) as noninvasive biomarkers for LUAD. A total of 110 participants were enrolled and randomly divided into two sets the discovery set (n=2 and the validation set (n=9. Exosomes w