https://www.selleckchem.com/pr....oducts/LY2603618-IC-
Furthermore, we established that isatuximab can directly activate natural killer (NK) cells and promote NK cell-mediated cytotoxicity via crosslinking of CD38 and CD16. Finally, isatuximab-induced CDC was observed in cell lines with high CD38 receptor density (250,000 molecules/cell) and limited expression of inhibitory complement regulatory proteins (CD46, CD55, and CD59; less then 50,000 molecules/cell). Taken together, our findings highlight mechanistic insights for isatuximab and provide support for a range of combinatio
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