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How a VC Can Affect Your Heart PVCs are common and can be experienced by a variety of people without causing any problems. If they happen frequently, PVCs may weaken your heart and increase the risk for heart failure. of fibers in the upper right-hand corner of your heart (the sinoatrial, or SA, node) typically controls your heart rhythm. Electrical signals are transmitted to the lower heart chambers or ventricles. Causes PVCs are caused when the electrical impulse that normally starts your heartbeat in a part kn