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pram, SSRIs used for 6 months doubled the risk of fractures in stroke survivors. Registration URL https//www.crd.york.ac.uk/prospero/; Unique identifier CRD42020192632. Very few large scale multicentric stroke clinical trials have been done in India. The Indian Council of Medical Research funded INSTRuCT (Indian Stroke Clinical Trial Network) as a task force project with the objectives to establish a state-of-the-art stroke clinical trial network and to conduct pharmacological and nonpharmacological stroke clinical trials relevant to the