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Experimental results demonstrate that DAIS is highly efficient to deal with a large area of missing teeth in arbitrary shapes and generate realistic occlusal surface completion. Moreover, the designed watertight inlay prostheses have enough anatomical morphology, thus providing higher clinical applicability compared with more state-of-the-art methods.Instance segmentation is of great importance for many biological applications, such as study of neural cell interactions, plant phenotyping, and quantitatively measuring how cells react to