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Also, GFAP+ astrocyte figures when you look at the hippocampus of the GFAP-IL6 mice were decreased by 42per cent. The GFAP-IL6 mice exhibited a different microglial morphology into the WT mice, showing an elevated soma size and perimeter. This difference ended up being significantly decreased because of the 874 PPM phytosomal curcumin dose. Our conclusions illustrate that phytosomal curcumin is able to attenuate the inflammatory pathology, and possibly reverse the harmful outcomes