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In the experimental stage, the authors use six different knowledge bases. The best results (the most often the clusters quality was improved) are achieved for two outlier detection algorithms LOF and COF.Understanding how nature drives entropy production offers novel insights regarding patient care. Whilst energy is always preserved and energy gradients irreversibly dissipate (thus producing entropy), increasing evidence suggests that they do so in the most optimal means possible. For living complex non-equilibrium systems to create a h