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Objective The present study aimed to analyze the risk factors correlated with overactive bladder (OA, observe the effects of desloratadine in the treatment of OAB, and explore the correlation between OAB and atopic constitution in children. Methods Correlation and binary logistic regression analysis of the medical data from 447 children clinically diagnosed with OAB from June 2019 to June 2020 were conducted. The data included a history of urticaria, eczema, itchy skin, and allergic rhinitis or allergic cough. The OABSS scores before an