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Lastly, the non-exponential kinetics of the looping process is also analyzed. We find that both activity and crowding can strengthen the heterogeneity degree of the looping kinetics.Raman spectroscopy is a non-invasive technique that allows specific chemical information to be obtained from various types of sample. The detailed molecular information that is present in Raman spectra permits monitoring of biochemical changes that occur in diseases, such as cancer, and can be used for the early detection and diagnosis of the disease, for m