https://www.selleckchem.com/pr....oducts/abc294640.htm
Meanwhile, the JAK1/STAT3 pathway was activated and accompanied by an increase in SASP secretion, such as IL-6, IL-8 and MMP9, while 0.8μM JAK1 inhibitor (JAKi) treatment could effectively inhibited the JAK pathway and SASP production. Furthermore, conditioned medium (CM) from irradiation-induced senescent (IRIS) BMSCs exhibited a markedly reduced ability in osteogenic differentiation and marker gene expression of osteoblasts, while CM with JAKi intervention may effectively improve this deterioration effects. In conclusion, irradiatio
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