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We sought to examine the natural history of geriatric assessment (GA) and quality of life (QOL) domains among adults age≥50years undergoing autologous hematopoietic cell transplantation (autoHCT). A QOL tool and cancer-specific GA were completed before autoHCT in patients ≥50years, and at 100days, six months, and one year post-transplant. One hundred eighty-four patients completed the pre-transplant QOL/GA assessment, 169 (92%) completed the 100-day assessment, 162 (88%) completed the six-month assessment, and 145 (79%) completed the t