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T-cell repertoire profiling from either side of the BBB concluded that the most frequent clones in the CSF samples are unique to an individual. Furthermore, we observed a difference in the proportion of expanded T-cell clones when comparing samples from MS patients in relapse and remission with opposite trends in CSF and peripheral blood. This study provides a characterization of the T cells in the CSF and might indicate a role of expanded clones in MS pathogenicity. This study provides a characterization of the T cells in the CSF and m
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