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This work may provide some inspiration for making use of normal substances in tumor treatment. This study had been carried out to analyze the effects of Inonotus obliquus polysaccharide (IOP) on reduced reproductive function as well as its systems in Toxoplasma gondii (T. gondii)-infected male mice. Results indicated that IOP significantly improved the spermatogenic capability and ameliorated pathological harm of testis, enhanced serum testosterone (T), luteinizing hormone (LH) an