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In this review, we provide an in-depth account of the development of ATSBs. We highlight the potential of ATSBs in controlling major Indian vectors of malaria and dengue, and we discuss possible challenges that could affect the efficacy of ATSBs in India. © 2020 Society of Chemical Industry. Simplified contraceptive method-efficacy and/or typical-use effectiveness rates are commonly used for direct comparison of the various contraceptive methods. Use of such effectiveness rates in this manner is, however, problematic in relation to the