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The median DNA-TG level in the 257 samples was 106.0 fmol TG/μg DNA (interquartile range, 75.8-150.9). There was a strong correlation between DNA-TG and RBC-TGN levels (ρ=0.68, 0.0001). The DNA-TG/RBC-TGN ratio was significantly higher in NUDT15 intermediate metabolizers ( and ) than in patients with wild-type alleles ( 0.0001). This simple and sensitive method for measuring DNA-TG level can improve therapeutic drug monitoring for thiopurine treatment. This simple and sensitive method for measuring DNA-TG level can improve ther
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