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Compared to lasso, adaptive lasso, elastic net, and DegreeCox, the ICM/M yielded more parsimonious models with consistent variable selection. The ICM/M model also provided a smaller number of false positives than the other methods and showed promising results in terms of predictive accuracy. In terms of computing times among the network-aware methods, the ICM/M algorithm is substantially faster than DegreeCox even when incorporating a large complex network. The implementation of the ICM/M algorithm for Cox regression model is provided in