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Over-expression of YAP rescued the suppressive effects of GRT on migration and invasion of CRPC cells. Treatment with the major flavonoid of GRT - the C-glucosyl dihydrochalcone, aspalathin - at a concentration of 75-100 μg/ml also reduced the migration and invasion of CRPC cells, and the inhibition was partially rescued by YAP over-expression. CONCLUSIONS GRT treatment suppresses the migration and invasion of CRPC cells via inhibition of YAP signaling and paxillin. In the last five years, several novel segmented RNA viruses have been d