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We discuss several examples where the one-two inequality applies. Finally, we briefly discuss the possible impact of the validity of a one-two inequality on directional error control in multiple testing.Fetal alcohol spectrum disorder (FASD) is the most common cause of birth defects. The severe variations are in fetal alcohol syndrome (FAS) but the most frequent cases are alcohol-related neurodevelopmental disorder (ARND), which is of a difficult diagnosis. ARND characteristics include impaired social behavior, anxiety and depression preva
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