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© 2020 The Authors. Thoracic Cancer posted by Asia Lung Oncology Group and John Wiley Sons Australia, Ltd.3q29 duplication problem (3q29dup) is an unusual genomic disorder caused by a 1.6 Mb replication (GRCh38 chr3195,998,000-197,623,00. Case reports indicate the 3q29dup will be pathogenic, but the complete variety of manifestations is not really comprehended. We used the 3q29 registry (https//3q29.com) to ascertain 31 individuals with 3q29dup, the greatest cohort ever surveyed