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This severely impairs lens transparency and results in blindness. Consistent with its highly conserved expression in differentiating lens fiber cells, the findings suggest that vertebrate Rbm24 represents a key regulator of cytoplasmic polyadenylation and plays an essential role in the posttranscriptional control of lens development. Copyright © 2020 the Author(s). Published by PNAS.Crises in science concern not only methods, statistics, and results but also, theory development. Beyond the indispensable refinement of tools and procedures