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009). By contrast, LT did not elicit a succinate response. Changes in succinate response were associated with changes in the area under the curve of glucose ( = 0.417, 0.0001) and insulin ( = 0.204, = 0.002). In cohort III, glycemia, per se, stimulated a plasma succinate response ( = 0.0004), but its response was greater in the OGTT ( = 0.02; OGTT versus IIGI). The meal-related response of circulating succinate in patients with obesity and type 2 diabetes is recovered after metabolic surgery. The meal-related response of circulatin