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Splenic lymphoma is commonly reported in domestic ferrets ( ), but very rarely reported in wild species, including otters. One report described B-cell splenic lymphoma in an Asian small-clawed otter ( ) that metastasized and was the primary reasoning for humane euthanasia (Stedman and Mills, 2014). The current report describes a case of splenic T-cell lymphoma in a captive North American river otter ( ). The otter died several weeks after splenectomy and no evidence of metastasis was found on gross necropsy or histopathological evaluat