https://www.selleckchem.com/mTOR.html
With the emergence of multidrug-resistant strains of Mycobacterium tuberculosis (MDR-T and extensive drug-resistant strains (XDR-T, there is an urgent need to develop novel drugs for the treatment of tuberculosis. Here, we designed and synthesized a series of 5-methylpyrimidopyridone analogues as potential antitubercular agents. The most potent compound 6q exhibited a MIC value of 4 μM in vitro against Mycobacterium tuberculosis. The antitubercular activities of the synthesized compounds were impacted by the amantadine and 2-chlorophenyl groups
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