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Typical location under the ROC for several five readers for CEUS, CUDI therefore the combination was 0.78, 0.79 and 0.78, correspondingly. This yields a sensitivity and specificity of 81 and 64% for CEUS, 83 and 56% for CUDI and 83 and 55% for the combination. Interobserver agreement for CEUS, CUDI as well as the combo revealed kappa values of 0.20, 0.18 and 0.18 correspondingly. CONCLUSION The sensitiveness and specificity of 2D CEUS and CUDI for csPCa localization tend to be modest. Despite